Publications in Peer-Reviewed Journals

1. Does nociception monitor‑guided anesthesia affect opioid consumption? A systematic review of randomized controlled trials
Fleur S. Meijer, Marieke Niesters, Monique van Velzen, Chris H. Martini, Erik Olofsen, Ruth Edry, Daniel I. Sessler, Eveline L. A. van Dorp, Albert Dahan, Martijn Boon
Journal of Clinical Monitoring and Computing 2019 July

2. Correlation between incremental remifentanil doses and the Nociception Level (NOL) index response after intraoperative noxious stimuli
Etienne Renaud-Roy, Pierre-André Stöckle, Sarah Maximos, Véronique Brulotte, Lucas Sideris, MD, Pierre Dubé, Pierre Drolet, MD, Issam Tanoubi, Rami Issa, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé.
Can J Anesth. 2019 April

3. Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial
Fleur Meijer, Chris Martini, Suzanne Broens, Martijn Boon, Marieke Niesters, Leon Aarts, Erik Olofsen, Monique van Velzen, Albert Dahan.
Anesthesiology 2019 February; doi:10.1097/ALN.0000000000002634

4. The nociception level index (NOL) response to intubation and incision in patients undergoing video-assisted thoracoscopic surgery (VATS) with and without thoracic epidural analgesia. A pilot study
Laurent Bollag, Srdjan Jelacic, Carlos Delgado Upegui, Cynthia Wu, Philippe Richebe.
F1000Research 2018 June; 7:875

5. Validation of the PMD100 and its NOL Index to detect nociception at different infusion regimen of remifentanil in patients under general anaesthesia
Pierre-André Stöckle, Marco Julien, Rami Issa, Elizabeth Décary, Véronique Brulotte, Pierre Drolet, Margaret Henri, Madeleine Poirier, Jean-François Latulippe, Marc Dorais, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé.
Minerva Anestesiol. 2018 Oct; 84(10):1160-1168

6. Monitoring the Nociception Level Intraoperatively – An Initial Experiences
Pether Jildenstål1, Katarina Hallén, Katarina Almskog, Johan Sand and Margareta Warren Stomberg.
J Anest & Inten Care Med. 2018; 7(2):1-5

7. Preliminary intraoperative validation of the NOL (Nociception Level) Index, a non-invasive nociception monitor
Ruth Edry, Vasile Recea, Yuri Dikust, Daniel I. Sessler.
Anesthesiology July 2016, Vol.125, 193-203

8. Ability of the Nociception Level (NOL), a multiparameter composite of autonomic signals, to detect noxious stimuli during propofol-remifentanil anesthesia
Chris H. Martini, Martijn Boon, Suzanne J. L. Broens, Evelien F. Hekkelman, Lisanne A. Oudhoff, Anna Willemijn Buddeke, Albert Dahan.
Anesthesiology Sept. 2015; 123:524-534

9. Monitoring the Nociception Level – A Multi-Parameter Approach
Nir Ben-Israel, Mark Kliger, Galit Zuckerman, Yeshayahu Katz, Ruth Edry.
Journal of Clinical Monitoring and Computing 2013 Dec.; 27(6):659-668

10. Differentiating between heat pain intensities: the combined effect of multiple autonomic parameters
Treister Roi, Kliger Mark, Zuckerman Galit, Itay Goor Aryeh, Eisenberg Elon.
PAIN® 2012 Sept.; 153(9):1807-14



Posters, Abstracts and Presentations

1. NOL index shows high sensitivity to detect nociception induced by intubation under different remifentanil dosages
Richebé P., McDevitt J., Boselli E., Sbeghen V., Topouzian G.S., Zaphirato V., Fortier L.P., Verdonck O.
CAS, Calgary, June 2019

2. Can NOL index calibration help to individualize remifentanil TCI before skin incision?
Max Bisdorff, Laurent Perrin, Ionut Tabolcea, Edgard Engelman, Luc Barvais
ESA, Vienna, June 2019

3. ED50 and ED95 of remifentanil for tracheal intubation as determined by a monitor of nociception (NOL index)
McDevitt J., Boselli E., Sbeghen V., Topouzian G. S., Verdonck O., Richebé P.
ESA, Vienna, June 2019

4. Anesthesia’s ultimate challenge: monitor intraoperative analgesia
Marta Vidal Seoane, Marta Pérez-De-Lis-Novo, C. Bonome González
ESA, Vienna, June 2019

5. Nocicepion Level (NOL)-guided Analgesia: Influence on Opioid Consumption and Hypotensive Events During Propofol/Remifentanil Anesthesia
Albert Dahan. Fleur S. Meijer, Suzanne Broens, Monique van Velzen, Christian Martini.
Awarded as “10 Best of Abstracts: Clinical Science” @ ASA, San Francisco, USA, October 2018

6. Combined Intraoperative Anesthesia & Analgesia Monitoring Impact on Safety & Recovery: CINAAMON Interim Analysis
Etienne Renaud-Roy, Philippe Richebé, Olivier Verdonck, Manon Choinière, Véronique Brulotte, Louis-Philippe Fortier.
ASA, San Francisco, USA, October 2018
CAS Annual Meeting, Montreal, Quebec, Canada, June 2018

7. Impact of Intravenous Phenylephrine Bolus on Intraoperative Nol Index Values
Philippe G.M. Richebe, Véronique Brulotte, Marie-Andree Coulombe, Etienne Renaud-Roy, Omar Elsemin, Manon Choiniere, Pierre Drolet, Louis-Philippe Fortier, Olivier Verdonck.
ASA, San Francisco, USA, October 2018

8. Performance Assessment of the PMD-200 in Subjects Requiring Surgery Under General Anesthesia
Virginia Horne, Borzoo Farhang, Alexander Friend, Max Breidstein.
ASA, San Francisco, USA, October 2018

9. Nol Index Response After Laryngoscopy Performed with Macintosh Blade Versus GlidescopeTM Videolaryngoscope
Virginie Sbeghen, Jason McDevitt, Olivier Verdonck, Valerie Zaphiratos, Veronique Brulotte, Christian Loubert, Pierre A. Drolet, Louis-Philippe Fortier, Marie-Claude Guertin, Philippe Richebé.
ASA, San Francisco, USA, October 2018
2018 CAS Annual Meeting, Montreal, Quebec, Canada, June 2018

10. Douleur Périopératoire et Délirium. Monitorage de La Nociception : Un nouveau paradigme multiparamétrique (NOL)
Dr Pierre-André Stöckle.
NOL technology symposia during SFAR, Paris, France, September 2018

11. Intraoperative nociception monitoring and postoperative recovery after knee arthroplasty
Patricia Lavand’homme, Emmanuel Thienpont.
IASP, Boston, USA, September 2018

12. Detection of Pain under General Anesthesia: Performance Assessment of the PMD-200
Virginia Horne, Alex Friend, Max Breidstein, Borzoo Farhang.
12th Annual New England Anesthesia Residents Conference (NEARC), Boston, Ma, USA, May 2018

13. O noua tehnica non-invaziva pentru monitorizarea durerii si optimizarea analgeziei intraoperatorii: indexul NOL
Serban Bubenek, Ruth Edry.
NOL technology symposia during SRATI congress, Sinaia, Romania, May 2018

14. Nociceptive monitoring during surgery during Mini-symposium: “Monitoring is our future”
Albert Dahan.
Leiden, The Netherlands, March, 2018

15. Missing a Piece? NOL™ (Nociception Level) Technology: Intraoperative Pain Monitoring for Optimizing Analgesia 
Ruth Edry, Daniel I. Sessler.
ICISA 2017, Tel Aviv, Israel, Nov. 2017

16. Tailoring analgesia to patients’ needs. The Nociception Level Index (NOL)
Albert Dahan.
3rd Symposium on Anesthesia, Organized by Hospital Da Luz, Lisbon, Portugal, Sept. 2017

17. Comment j’individualise l’analgésie péeriopératoire
Philippe G. Richebe.
SFAR Congress, Paris, France, Sept. 2017

18. Impact of different remifentanil doses on the nociception level index response to intra- operative noxious stimuli
Etienne Renaud-Roy, Pierre-André Stöckle, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé.
CAS, Niagara Falls, ON, Canada, June 2017 (pages 6-7)
Euroanaesthesia, Geneva, Switzerland, May 2017 (page 41)

19. NOL Index performance in patients with beta-blockers
Ruth Edry, Vasile Recea, Yuri Dikust
Euroanaesthesia, Geneva, Switzerland, May 2017 (page 234)

20. Physiologic Indicators for the assessment of acute pain: Recent evidence and new trends
Céline Gélinas.
Canadian Pain Society, May 2017 (p. A36-A37)

21. Developing a Monitor Process Perspective.
Dr. Ruth Edry – oral presentation at the 2016 Annual Meeting of the Israeli Society of Anesthesiology, December 2016

22. Quantified Analgesic Effect of Intraoperative 50% N2O Inhalation by the NOL and ANI Nociception Indices
Philippe G. Richebe, Elizabeth Decary, Rami Issa, Sarah Maximos, Louis-Philippe Fortier, Olivier Verdonck.
ASA (American Society of Anesthesiologists), Chicago, IL, USA, 2016

23. NOL index variation after standardized nociceptive stimulus decreases with higher doses of remifentanil
Marco Julien, Elizabeth Décary, Rami Issa, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé.
EuroAnesthesia – ESA (European Society of Anaesthesiology). London, UK, 2016

24. Ability of the nociception level, a Multiparameter Composite of Autonomic Signals, to detect noxious stimuli during propofol-remifentanil anesthesia
Chris Martini, Martijn Boon, Albert Dahan.
ASA (American Society of Anesthesiologists), San Diego, USA, Oct. 2015

25. The level of nociception (NOL) in thoracotomy patients with and without epidural analgesia
Laurent Bollag, Srdjan Jelacic, Cynthia Wu, Philippe Richebé.
EFIC Pain Congress, Vienna, Austria, Sept. 2015

26. Validation of nociception monitor – The NOL Index
Ruth Edry, Vasile Recea, Yuri Dikust, Daniel I. Sessler.
EuroAnesthesia  – ESA (European Society of Anaesthesiology), Germany, June 2015 (1AP12-6, page 53)

27. Objective assessment of spinal cord stimulation effectiveness on chronic radicular pain
Nir Ben-Israel, Yariv Amos, Noam Racheli, Mark Kliger, Galit Zuckerman, Roi Treister, Elon Eisenberg.
IASP (International Association for the Study of Pain Annual Meeting), Argentina, Oct. 2014

28. Objective measurement of pain levels in patients with radicular pain treated by spinal cord stimulation
Nir Ben-Israel, Yariv Amos, Mark Kliger, Galit Zuckerman, Erica Suzan, Elon Eisenberg.
AAPM (American Academy of Pain Medicine Annual Meeting), AZ, USA,  Mar. 2014

29. Detection of noxious stimuli during general anesthesia using the NOL index for nociception level
Edry Ruth, Kliger Mark, Zuckerman Galit, Racheli Noam, Katz Yeshayahu, Ben-Israel Nir.
EuroAnesthesia – ESA (European Society of Anaesthesiology), Barcelona, Spain, June 2013

30. Non-linear Multi-Parameter Approach for Evaluation of Nociception Level During General Anesthesia
Ben-Israel Nir, Zuckerman Galit, Kliger Mark, Katz Yeshayahu, Edry Ruth.
STA (Society for Technology in Anesthesia), Phoenix, AZ, Jan. 2013
ASA (American Society of Anesthesiologists), Washington DC, Oct. 2012

31. A combination of multiple autonomic parameters, rather than each parameter alone, yields significant differentiation between heat pain intensities
Roi Treister, Mark Kliger, Galit Zuckerman, Itay Goor Aryeh, Elon Eisenberg.
EFIC  Pain Conference, Germany, 2011

32. Toward automatic pain monitoring: Method for classification of pain level based on statistical processing of multiple non-invasive physiological measures
Roi Treister, Mark Kliger, Galit Zuckerman, Itay Goor Aryeh, Elon Eisenberg.
IPA Conference, Israel, 2010



Key Citations and Reviews

1. Assessing nociception: steps towards intraoperative “full monitoring” ‒ Editorial Review
Manuel Á. Gómez-Ríos, Alfredo Abad-Gurumeta, José M. Calvo-Vecino
Minerva Anestesiologica 2018 Oct.; 84(10):1123-5

2. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
John W Devlin, Yoanna Skrobik, Céline Gélinas, John Needham et al.
Crit Care Med. 2018 Sep; 46(9):e825-e873 

3. Le monitorage de la douleur peropératoire : actualités et perspectives (Intraoperative pain monitoring: Update and future directions)
Pierre-André Stöckle, Philippe Richebé
Anesthésie & Réanimation 2018 May; 4(3):204-214

4. Next steps in ICU pain research
Kathleen Puntillo , Céline Gélinas and Gerald Chanques
Intensive Care Med. 2017 Sep; 43(9):1386-1388

5. Digital innovations and emerging technologies for enhanced recovery programmes
Frederic Michard, Tong Joo (TJ) Gan, Henrik Kehlet
Br J Anaesth 2017; 119(1):31-39

6. Objective Assessment of Acute Pain
Helen Laycock, Carsten Bantel.
J Anesth Clin Res 2016, 7:6

7. Physiological Signal Processing for Individualized Anti-nociception Management During General Anesthesia: a Review.
Julien De Jonckheere, Vincent Bonhomme, Mathieu Jeanne, Emmanuel Boselli, Matthias Gruenewald, Regis Logier, Philippe Richebé.
Yearb Med Inform. 2015 Aug 13;10(1):95-101

8. Assessing pain objectively: the use of physiological markers
Rachel Cowen, Maria Stasiowska, Helen Laycock, Carsten Bantel.
Anaesthesia. 2015 July ;70(7):828-47

9. Acute psychosocial stress reduces pain modulation capabilities in healthy men
Geva Nirit, Pruessner Jens, Defrin Ruth.
PAIN® 2014 Nov.;155(11):2418-25

10. Multi-parameter autonomic-based pain assessment: More is more?
Marco L. Loggia, Vitaly Napadow.
PAIN® 2012; 153:1779–1780