The cost of pain during surgery

To the patient

Although not consciously renurse anesthesist + patientcognised, during general anaesthetic the patient’s body reacts to painful stimuli. Intraoperative pain can cause stress to the patient’s body1-4 and as the patient is unconscious during surgery they are unable to communicate how they are feeling, making evaluation of the situation difficult. Throughout the surgical procedure, anesthetised patients are continuously monitored for hypnosis and muscle relaxation. Nociception/analgesia are currently assessed by monitoring changes in heart rate (HR), blood pressure (BP), and other indirect parameters which are not sensitive or specific to nociception. As a result, the patient may be given insufficient analgesia which can promote postoperative pain, or excessive analgesia which can result in overdosing and related complications5-8. In addition to pain, upon regaining consciousness after surgery, common complications resulting from opioid administration include nausea, vomiting, respiratory depression, constipation 9 and hyperalgesia10.  Current data shows up to 62% of patients suffer from moderate/extreme pain immediately after surgery11 and 12.2% suffer from an opioid-related adverse drug event (ORADE) complications12.

To the healthcare system

On average, post-operative complications result in an additional 3.4 extra days of hospitalisation per adverse event which produces an added cost of 27% per patient (on average US$4,707 per person) and an increase in re-admissions12. Patient dissatisfaction is strongly associated with insufficient postoperative pain relief therefore optimal perioperative pain management is a key to increase the physical, mental and social well-being of patients11.



It has always been notoriously difficult to quantitatively measure pain. It is conditional on the patient’s subjective assessment of how much pain they are in and their ability to communicate this effectively. For those who are unable to communicate or find it difficult (e.g. those anesthetised), the clinicians responsible must rely on surrogate parameters which are not specific nor sensitive enough to pain.

The importance of measuring pain cannot be underestimated; it may contribute to the treatment pathway the patient will take. Currently there are no validated objective markers of nociception or pain that can be recommended for clinical use13 although measurements taken through monitoring haemodynamic and clinical parameters, such as heart rate, blood pressure, sweating etc., can aid clinician interpretation.  It is accepted that measurements extracted as a result of these singular assessments are not specific to pain and may be caused by something unrelated, which can weaken the validity.





The consensus amongst healthcare professionals is that accurate assessment of a patient’s pain is a crucial component of pain management and can achieve:

  • Increased patient satisfaction14
  • Earlier mobilisation
  • Fewer pulmonary and cardiac complications
  • Reduced risk of deep vein thrombosis
  • Reduced cost of care15



Treatment of acute and chronic pain - Medasense

Treating pain is at the heart of medicine and increasing patients’ quality of life as a result of easing pain is an essential role of every healthcare professional. Pain represents a major clinical, social and economic problem16 and affects the quality of life for hundreds of millions of people globally, with almost one in five surveyed Europeans reporting to have moderate or severe chronic pain17 and nearly 69,000 people dying every year globally from an overdose of painkillers18. In Europe, national healthcare and socioeconomic costs of conditions associated with chronic pain run into billions annually and represent 3–10% of gross domestic product17. The inability to quantitatively communicate or measure it only exacerbates the problem.


To download the full document in pdf click here


  1. Desborough JP., (2000) The stress response to trauma and surgery, Br J Anaesth 85:109–117
  2. Dickerson DM., (2014) Acute pain management. Anesthesiol Clin. 32:495-504
  3. McGreevy K., (2011) Preventing Chronic Pain following Acute Pain: Risk Factors, Preventive Strategies, and their Efficacy. Eur J Pain Suppl. 5:365–337
  4. Kehlet H et al., (2006) Persistent postsurgical pain: risk factors and prevention, Lancet
  5. Smith HS et al., (2014) Opioid induced nausea and vomiting. Eur J Pharmacol. 722:67-78
  6. Kehlet H et al., (1997) Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth 78:606–617
  7. Gayatri P., (2005) Post-op pain services. Indian J. Anaesth. 49:17-19
  8. Lee LA et al., (2015) Postoperative Opioid-induced Respiratory Depression: A Closed Claims Analysis. Anesthesiology 122:659-665
  9. Benyamin R et al., (2008) Opioid complications and side effects. Pain Physician.11:S105-120.
  10. Joly V et al., (2005) Remifentanil-induced postoperative hyperalgesia and its prevention with small dose ketamine. Anesthesiology, 103:147-55
  11. Gan TJ et al., (2014) Incidence, patient satisfaction, and perceptions of post-surgical pain: Results from a US national survey. Current Medical Research and
    . 30:149–60
  12. Oderda G et al., (2013) Effect of Opioid-Related Adverse Events on Outcomes in Selected Surgical Patients. J Pain Palliat Care Pharmacother, 27:62-70
  13. Cowen R et al., (2015) Assessing pain objectively: the use of physiological markers. Anaesthesia, 70:828-847
  14. Wood S. (2008) Assessment of pain. Nursing Times [online] accessed 13 January 2017
  15. Ramsay M. (2000) Acute Postoperative Pain Management. Proc (Bayl Univ Med Cent), 13:244–247.
  16. Phillips C. (2009) The Cost and Burden of Chronic Pain. Rev Pain, 3:2–5.
  17. Breivik H et al., (2013) The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge
    and availability of appropriate care. BMC Public Health, 13: 1229.
  18. World Health Organisation (2014) Information sheet on opioid overdose. World Health Organisation [online], accessed 13 January 2017